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991.
Chalmers JD Mandal P Singanayagam A Akram AR Choudhury G Short PM Hill AT 《Intensive care medicine》2011,37(9):1409-1420
Background
The aim of this meta-analysis was to determine if severity assessment tools can be used to guide decisions regarding intensive care unit (ICU) admission of patients with community-acquired pneumonia. 相似文献992.
Bertolini G Rossi C Crespi D Finazzi S Morandotti M Rossi S Peta M Langer M Poole D 《Intensive care medicine》2011,37(11):1746-1755
Purpose
Uncertainty about the severity of the A(H1N1) pandemia persists. Information about disease severity can be obtained by investigating intensive care unit (ICU) admissions, especially when historical comparisons can be made with cases of community-acquired pneumonia (CAP). 相似文献993.
Background The purpose of this study was to evaluate whether an electronic-colonic-cleansing (ECC) algorithm is beneficial for the diagnostic
performance compared to a CT colonography (CTC) evaluation without electronic cleansing in tagged datasets.
Methods Two blinded readers evaluated CTC datasets from 79 patients with 153 colorectal polyps confirmed by optical colonoscopy. Cases
were read in a randomized order with and without the use of electronic colon-cleansing software. Per-polyp sensitivity, per-polyp/per-patient
specificity and reading times (with and without ECC) have been calculated and reported.
Results Per-polyp sensitivity for polyps >6 mm without using ECC was 60.4% (Reader 1: 59.7%, Reader 2: 61.1%), while polyps >10 mm
were detected with a sensitivity of 58.3% (Reader 1: 66.7%, Reader 2: 50%). On electronically cleansed datasets, the sensitivity
was 73.6% (Reader 1: 76.4%; Reader 2: 70.8%) for polyps >6 mm and 83.3% (Reader 1: 83.3%; Reader 2: 83.3%), respectively.
Per-patient specificity was 75% without using cleansing (Reader 1: 68%, Reader 2: 82%) and 81.5% using ECC (Reader 1: 86%,
Reader 2: 77%).
Conclusion Reading CTC cases using ECC software improves sensitivity in detecting clinically relevant colorectal polyps. 相似文献
994.
995.
目的:脊髓损伤膀胱功能障碍患者采用八穴药物注射配合膀胱功能训练与单纯膀胱功能训练进行疗效对比观察。方法:选择2001-10/2004-03在广州工伤康复医院住院的脊髓损伤膀胱功能障碍患者24例,随机分为两组,治疗组12例,对照组12例。治疗组采用膀胱功能训练配合八穴药物注射疗法。①八穴药物注射:将维生素B1200mg+维生素B12500μg+生理盐水3~5mL,注入上穴,次穴,中穴,下穴,每穴位注入2~2.5mL,1次/d,两侧穴位每天交替注射,10d为1个疗程,平均治疗2~4个疗程,每疗程间隔3~5d。②膀胱功能训练的方法:限制饮水量,24h总入水量控制在2500mL左右;依据残余尿量多少进行间歇导尿。③对照组仅行上述膀胱功能训练方法。④膀胱功能评定以自主性排尿节律,勿需导尿管排尿,残余尿量<100mL为显效;导尿次数减少,残余尿量100~150mL为有效;无明显改善为无效。结果:按意向处理分析,24例患者均进入结果分析。治疗组显效5例,有效5例,无效2例。对照组显效2例,有效2例,无效8例。治疗组总有效率显著高于对照组犤83%(10/12),33%(4/10),χ2=4.29,P<0.05犦。结论:采用八穴药物注射配合膀胱功能训练治疗脊髓损伤膀胱功能障碍患者,比单纯的膀胱功能训练方法疗效显著。说明八穴药物注射后,发挥了穴位和药物的综合治疗作用,能有效的改善脊髓损伤后的膀胱功能。 相似文献
996.
Migraine genetics: An update 总被引:1,自引:0,他引:1
Haan J Kors EE Vanmolkot KR van den Maagdenberg AM Frants RR Ferrari MD 《Current pain and headache reports》2005,9(3):213-220
A growing interest in genetic research in migraine has resulted in the identification of several chromosomal regions that
are involved in migraine. However, the identification of mutations in the genes for familial hemiplegic migraine (FHM) forms
the only true molecular genetic knowledge of migraine thus far. The increased number of mutations in the FHM1 (CACNA1A) and the FHM2 (ATP1A2) genes allow studying the relationship between genetic findings in both genes and the clinical features in patients. A wide
spectrum of symptoms is seen in patients. Additional cerebellar ataxia and (childhood) epilepsy can occur in FHM1 and FHM2.
Functional studies show a dysfunction in ion transport as the key factor in the pathophysiology of (familial hemiplegic) migraine
that predict an increased susceptibility to cortical spreading depression—the underlying mechanism of migraine aura. 相似文献
997.
Goadsby PJ 《Current pain and headache reports》2004,8(5):393-398
There now is one realized and several attractive targets for the treatment of acute attacks of migraine that will follow and
augment the use of serotonin 5-HT1B/1D receptor agonists, the triptans. Calcitonin gene-related peptide (CGRP) receptor blockade
recently has been shown to be an effective acute antimigraine strategy; therefore, blockade of CGRP release by inhibition
of trigeminal nerves would seem a logical approach. A number of targets are reviewed in this article including serotonin 5-HT1F
and 5-HT1D receptors, adenosine A1 receptors, nociceptin, vanilloid TRPV1 receptors, and anandamide CB1 receptors. Development
of one or more such compound offers the exciting prospect of new non-vasoconstrictor treatments for migraine and cluster headache. 相似文献
998.
Inhibition of IL-12 production by 1,25-dihydroxyvitamin D3. Involvement of NF-kappaB downregulation in transcriptional repression of the p40 gene. 下载免费PDF全文
999.
Ángel Matute-Llorente Alejandro González-Agüero Luis A. Moreno-Aznar José A. Casajús 《Journal of developmental and physical disabilities》2017,29(4):611-624
Vitamin D (vitD) deficiency is a worldwide problem. Therefore, the main aims of this study were to compare 25-hydroxivitamin D levels (25(OH)D) in adolescents with and without Down syndrome (DS) and to study the relationship between 25(OH)D and bone. Eleven adolescents with DS (6 females) aged 15.5 ± 2.8 years and sixteen healthy controls (non-DS) (6 females) aged 14.3 ± 2.2 years were evaluated by bone imaging techniques. Blood samples were collected to determine vitD levels. Independent t-tests and analyses of covariance controlling for age, height, sex, sexual maturation, calcium intake and body mass index were performed to evaluate differences in 25(OH)D levels between groups. Pearson’s correlation test and multiple linear regression analyses were performed to examine the association between 25(OH)D and bone mass. Adolescents with DS had lower 25(OH)D (22.8 ± 8.0 vs. 36.0 ± 6.5 ng/ml) than non-DS (d = 1.81; p < 0.05). Only 18% of participants with DS reached the recommended level of 30 ng/ml of 25(OH)D. No significant group interactions were found for any bone variable (all p > 0.05) but linear regression analyses suggested that 25(OH)D influenced positively femoral neck bone mineral density (β = 0.477, p = 0.038) and content at the 4% of the length of the tibia (β = 0.453, p = 0.008) in the non-DS and cortical volumetric bone mineral density at the 38% (β = 0.841, p = 0.034) in the DS. Adolescents with DS had lower levels of 25(OH)D and higher prevalence of vitD deficiency compared with non-DS. Associations between 25(OH)D and bone parameters were not observed for adolescents with DS but medium and positive correlations were observed in the non-DS group. 相似文献
1000.
Stefan Raith Sebastian Wolff Timm Steiner Ali Modabber Michael Weber Frank Hölzle Horst Fischer 《International journal of computer assisted radiology and surgery》2017,12(1):99-112